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The Endocannabinoid Production in the Human Body

Shortly after the first cannabinoid was isolated from the cannabis plant, scientists discovered that the human body produces similar substances on its own. These substances are now known as “endogenous cannabinoids.” Not only do humans produce their own cannabinoids, but they also have receptors designed specifically to recognize and respond to the endogenous cannabinoids produced.

Together, the body’s endogenous cannabinoids and the receptors that bind with them form the endocannabinoid system. This system is responsible for a number of functions within the human body, such as maintaining homeostasis.


How it Works

The body’s endocannabinoid system relies on the natural production of endogenous cannabinoids in order to function properly. In order to produce the proper amount of endogenous cannabinoids, the body requires a sufficient amount of Omega-3 fatty acids.

Omega-3 fatty acids are the precursor to endogenous cannabinoids. If they are in short supply, the body will not be able to manufacture the amount of endogenous cannabinoids it needs to maintain a healthy endocannabinoid system. In addition, Omega-3 fatty acids are also essential to the health of other components in the endocannabinoid system. For example, these compounds facilitate the growth and healing of CB1 receptors, which are required in order to process cannabinoids of any type. Furthermore, Omega-3s are important for the overall health of brain cells in general.


Omega-3 Deficiencies

If your diet doesn’t contain a sufficient amount of Omega-3 fatty acids, your body may be unable to produce the proper amount of endogenous cannabinoids on its own. In addition, because Omega-3 fatty acids grow and repair your CB1 receptors, the cannabinoids your body does produce may not affect the endocannabinoid system as strongly as they should. For this reason, it is important for everyone to eat a diet high in Omega-3 fatty acids. Not only are these compounds important for the endocannabinoid system, but they also promote human health in general by boosting fertility, lowering cholesterol, lubricating the joints, protecting vision, improving heart health and providing a number of other important benefits.

Endocannabinoid Deficiency Syndrome

Unfortunately, modern diets do not always contain the nutrition required to maintain the endocannabinoid system properly. In cases where nutritional deficiencies or other problems are causing the endocannabinoid system to fail, a person may develop a condition known as “Endocannabinoid Deficiency Syndrome”. This can lead to a variety of symptoms and related conditions, including irritable bowel syndrome, fibromyalgia, migraines and more.

Treatment Options

If you are suffering from Endocannabinoid Deficiency Syndrome, you may be able to improve your condition by increasing the amount of Omega-3 fatty acids in your diet. This will help to heal your CB1 receptors, facilitate the growth of more receptors and increase the amount of endogenous cannabinoids your body produces. It may also be helpful to supplement your body’s endogenous cannabinoids with cannabinoids from external sources, such as UnTamed Life CBD Cannabidiol. Taking a cannabidiol supplement will increase the concentration of cannabinoids in your body, thus leading to a more efficient and
effective endocannabinoid system.

 

How Does CBD Affect the Endocannabinoid System?

The endocannabinoid system exists to respond to endogenous cannabinoids produced by the human body. However, scientists have learned that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol. According to the National Institutes of Health, manipulating the endocannabinoid system by introducing external cannabinoids like UnTamed Life CBD Oil could be useful in treating a variety of medical ailments.

CBD and Cannabinoid Receptors

The endocannabinoid system includes two primary types of receptors that bind to cannabinoids: CB1 and CB2. Unlike THC, which fits directly into the CB1 receptor, cannabidiol does not fit into either type of receptor perfectly. Instead, it stimulates activity in both receptors without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.
According to Project CBD, research has also shown that CBD counteracts the psychoactive effects of THC by inhibiting its effects on CB1 receptors.


CBD’s Indirect Effects on the Endocannabinoid System

When introduced into the endocannabinoid system, CBD causes an increased release of 2-AG, one of the endogenous cannabinoids. Like CBD, 2-AG stimulates both CB1 and CB2 receptors, which enhances the overall effect on the body. Studies published by the National Institutes of Health have shown that cannabidiol also inhibits the activity of fatty acid amide hydroxylase, or FAAH. This slows the deterioration of anandamide, another important endogenous cannabinoid found naturally within the body.

Other Effects of CBD

In addition to its impact on the endocannabinoid system, CBD also affects the body in other ways. For example, CBD binds directly to a G-protein coupled receptor known as TRPV-1, which is responsible for mediating body temperature, perceptions of pain and inflammation. CBD also activates serotonin receptors. Furthermore, studies conducted by the California Pacific Medical Center have shown that cannabidiol has the power to inhibit the ID-1 gene, which is known to cause several aggressive cancers, including certain cancers of the breast, brain, lungs, ovaries and pancreas.

Implications in Medicine

Cannabidiol’s impact on the endocannabinoid system, as well as its other effects on the human body, indicate that this substance may be useful in treating a variety of medical conditions. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemo. Because CBD inhibits the negative effects of THC, it stands to reason that administering the two substances together could be even more beneficial than treatment with THC alone. Likewise, cannabidiol’s stimulation of the endocannabinoid system promotes homeostasis within the body, reduces sensations of pain and inhibits inflammatory processes.
 
Finally, CBD’s effects on other genes and systems, such as its inhibition of the ID-1 gene, indicate that it may be an ideal treatment for certain types of effective cancers.

Medical research involving the possible uses of CBD is ongoing, the list of conditions CBD could potentially treat continues to grow. Currently, the list includes the conditions listed above, as well as mood disorders, diabetes, heart disease, glaucoma, asthma, stroke and many more.